Human MUC16(13810-14451) Protein; His Tag
Product Sizes
50 µg
£634.00
32-18248-50UG
100 µg
£750.00
32-18248-100UG
About this Product
- SKU:
- 32-18248
- Additional Names:
- CA125
- Extra Details:
- Description :Recombinant human MUC16(13810-14451) Protein with C-terminal 10XHis tag Background : This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight; O-glycosylated proteins that play an important role in forming a protective mucous barrier; and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus; a large tandem repeat domain; and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated; while the repeat region contains 156 amino acid repeats unit that are rich in serines; threonines; and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules; leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain; and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier; protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers; with higher expression levels associated with poorer outcomes. Molecular Characterization: mass of 73.2 kDa after removal of the signal peptide. The apparent molecular mass of MUC16(13810-14451)-His is approximately 100-130 kDa due to glycosylation. Tag :C-10XHis tag
- Host:
- HEK293
- Purification:
- The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
