Human VEGF165 Protein; hFc Tag
Product Sizes
50 µg
£688.00
32-18232-50UG
100 µg
£832.00
32-18232-100UG
About this Product
- SKU:
- 32-18232
- Additional Names:
- MVCD1; VEGF; VPF; VEGFA
- Extra Details:
- Description :Recombinant human VEGF165 Protein with C-terminal human Fc tagBackground: VEGF165 is the most abundant splice variant of VEGF-A. VEGF165 is produced by a number of cells including endothelial cells; macrophages and T cells. VEGF165 is involved in angiogenesis; vascular endothelial cell survival; growth; migration and vascular permeability. VEGF gene expression is induced by hypoxia; inflammatory cytokines and oncogenes. VEGF165 binds to heparan sulfate and is retained on the cell surface and in the extracellular matrix. VEGF165 binds to the receptor tyrosine kinases; VEGFR1 and VEGFR2. VEGF165 is the only splice variant that binds to co-receptors NRP-1 and NRP-2 that function to enhance VEGFR2 signaling. Binding of VEGF165 to VEGFR1 and VEGFR2 leads to activation of the PI3K/AKT; p38 MAPK; FAK and paxillin. VEGF plays a key role in tumor angiogenesis in many cancers.Description: Recombinant human VEGF165 Protein with C-terminal human Fc tagMolecular Characterization: VEGF165(Ala27-Arg191) hFc(Glu99-Ala330)Molecular Weight :The protein has a predicted molecular mass of 45.3 kDa after removal of the signal peptide. The apparent molecular mass of VEGF165-hFc is approximately 35-55 kDa due to glycosylation.Tag :C-Human Fc tag
- Host:
- HEK293
- Purification:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
