Human VEGF121 Protein; hFc Tag
Product Sizes
50 µg
£688.00
32-18231-50UG
100 µg
£832.00
32-18231-100UG
About this Product
- SKU:
- 32-18231
- Additional Names:
- MVCD1; VEGF; VPF; VEGFA
- Extra Details:
- Description :Recombinant human VEGF121 Protein with C-terminal human Fc tagBackground: Vascular endothelial growth factor (VEGF) is also known as vascular permeability factor (VPF) and VEGF-A; and is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects; including mediating increased vascular permeability; inducing angiogenesis; vasculogenesis and endothelial cell growth; promoting cell migration; and inhibiting apoptosis. Alternatively spliced transcript variants; encoding either freely secreted or cell-associated isoforms; have been characterized. Alternatively spliced isoforms of 121;145;165;183;189 and 206 amino acids in length are expressed in humans. VEGF165 appears to be the most abundant and potent isoform; followed by VEGF121 and VEGF189. VEGF121 is the only form that lacks a basic heparinbinding region and is freely diffusible. Mouse embryos expressing only the corresponding isoform (VEGF120) do not survive to term; and show defects in skeletogenesis. Human VEGF121 shares 87% aa sequence identity with corresponding regions of mouse and rat; 93% with feline; equine and bovine; and 91%; 95% and 96% with ovine; canine and porcine VEGF; respectively. VEGF121 induces the proliferation of lymphatic endothelial cells. The lymphangiogenesis may be promoted by upregulation of VEGF121; which may in turn act in part via induction of VEGF-C.Description: Recombinant human VEGF121 Protein with C-terminal human Fc tagMolecular Characterization: VEGF121(Ala27-Arg147) hFc(Glu99-Ala330)Molecular Weight :The protein has a predicted molecular mass of 40.2 kDa after removal of the signal peptide. The apparent molecular mass of VEGF121-hFc is approximately 35-55 kDa due to glycosylation.Tag :C-Human Fc tag
- Host:
- HEK293
- Purification:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
