Recombinant Human PILRA Protein; hFc Tag
Product Sizes
50 µg
£635.00
32-18211-50UG
100 µg
£752.00
32-18211-100UG
About this Product
- SKU:
- 32-18211
- Additional Names:
- FDF03
- Extra Details:
- Molecular Characterization: PILRA(Gln20-Glu195) hFc(Glu99-Ala330)Molecular weight: The protein has a predicted molecular mass of 46.2 kDa after removal of the signal peptide. The apparent molecular mass of PILRA-hFc is approximately 55-70 kDa due to glycosylation.Description: Recombinant Human PILRA Protein with C-terminal human Fc tagCell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing; activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair; which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants; each encoding a distinct isoform; are described.
- Host:
- HEK293
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
