Recombinant Human ACHE Protein; His Tag
Product Sizes
50 µg
£656.00
32-18168-50UG
100 µg
£781.00
32-18168-100UG
About this Product
- SKU:
- 32-18168
- Additional Names:
- ACEE; ARACHE; N-ACHE; YT
- Extra Details:
- Molecular Characterization: ACHE(Glu32-Leu614)6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 65.4 kDa after removal of the signal peptide. The apparent molecular mass of ACHE-His is approximately 55-70 kDa due to glycosylation.Description: Recombinant Human ACHE Protein with C-terminal6Ã-His tagAcetylcholinesterase hydrolyzes the neurotransmitter; acetylcholine at neuromuscular junctions and brain cholinergic synapses; and thus terminates signal transmission. It is also found on the red blood cell membranes; where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties; but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene; and the structural diversity in the gene products arises from alternative mRNA splicing; and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain; muscle and other tissues is the hydrophilic species; which forms disulfide-linked oligomers with collagenous; or lipid-containing structural subunits. The other; alternatively spliced form; expressed primarily in the erythroid tissues; differs at the C-terminal end; and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. AChE activity may constitute a sensitive biomarker of RBC ageing in vivo; and thus; may be of aid in understanding the effects of transfusion
- Host:
- HEK293
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
