Recombinant Human IL23A & IL12B Heterodimer Protein; hFc Tag & His Tag
Product Sizes
50 µg
£622.00
32-18160-50UG
100 µg
£732.00
32-18160-100UG
About this Product
- SKU:
- 32-18160
- Additional Names:
- IL-23; IL-23A; IL23P19; P19; SGRF & CLMF; CLMF2; IL-12B; IMD28; IMD29; NKSF; NKSF2
- Extra Details:
- Molecular Characterization: IL23A(Arg20-Pro189) hFc(Glu99-Ala330)and IL12B(Ile23-Ser328)6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 44.8 and 35.5 kDa after removal of the signal peptide. The apparent molecular mass of IL23A-hFc and IL12B-His is approximately 35-55 kDa due to glycosylation.Description: Recombinant human IL23A protein with C-terminal human Fc tag and human IL12B protein with C-terminal6Ã-His tagInterleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin; a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R; activates the Jak-Stat signaling cascade; stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
- Host:
- HEK293
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
