Recombinant Human Selenop Protein; Flag Tag
Product Sizes
50 µg
£656.00
32-18151-50UG
100 µg
£781.00
32-18151-100UG
About this Product
- SKU:
- 32-18151
- Additional Names:
- SELP; SeP; SEPP; SEPP1
- Extra Details:
- Molecular Characterization: Selenop?Met1-Asn381?+3×Flag tag Molecular Weight: The protein has a predicted molecular mass of 42.5 kDa after removal of the signal peptide. Description: Recombinant Human Selenop Protein with C-terminal 3×flag tag This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human); and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant; and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction; suggesting its importance in normal brain function. Sec is encoded by the UGA codon; which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure; designated the Sec insertion sequence (SECIS) element; that is necessary for the recognition of UGA as a Sec codon; rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites; one located in between the two SECIS elements; results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene.
- Host:
- HEK293
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
