Recombinant Human FURIN Protein; His Tag
Product Sizes
50 µg
£823.00
32-17997-50UG
100 µg
£1019.00
32-17997-100UG
About this Product
- SKU:
- 32-17997
- Additional Names:
- FUR; PACE; PCSK3; SPC1
- Extra Details:
- Molecular Characterization: FURIN(Gln27-Ala574)6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 61.0 kDa after removal of the signal peptide. The apparent molecular mass of FURIN-His is approximately 55-70 kDa due to glycosylation.Description: Recombinant human FURIN protein with C-terminal6Ã-His tagThis gene encodes a member of the subtilisin-like proprotein convertase family; which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues; including neuroendocrine; liver; gut; and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. Like other members of this convertase family; the product of this gene specifically cleaves substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone; transforming growth factor beta 1 precursor; proalbumin; pro-beta-secretase; membrane type-1 matrix metalloproteinase; beta subunit of pro-nerve growth factor and von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140; and may play a role in tumor progression. Unlike SARS-CoV and other coronaviruses; the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by this protease. Alternative splicing results in multiple transcript variants.
- Host:
- HEK293
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
