Recombinant Human CD59 Protein; hFc Tag
Product Sizes
50 µg
£750.00
32-17984-50UG
100 µg
£911.00
32-17984-100UG
About this Product
- SKU:
- 32-17984
- Additional Names:
- HRF20; MAC-IP; MACIF; MIRL; MIC11; MIN1; MIN2; MIN3; MSK21
- Extra Details:
- Molecular Characterization: CD59(Leu26-Asn102) hFc(Glu99-Ala330)Molecular weight: The protein has a predicted molecular mass of 35.1 kDa after removal of the signal peptide. The apparent molecular mass of CD59-hFc is approximately 40-53 kDa due to glycosylation.Description: Recombinant human CD59 protein with C-terminal human Fc tagThis gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis; and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex; whereby it binds complement C8 and/or C9 during the assembly of this complex; thereby inhibiting the incorporation of multiple copies of C9 into the complex; which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency; a disease resulting in hemolytic anemia and thrombosis; and which causes cerebral infarction. Multiple alternatively spliced transcript variants; which encode the same protein; have been identified for this gene.
- Host:
- HEK293
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
