Recombinant Mouse NKG2D Protein; hFc Tag
Product Sizes
50 µg
£750.00
32-17960-50UG
100 µg
£911.00
32-17960-100UG
About this Product
- SKU:
- 32-17960
- Additional Names:
- NK cell receptor D; CD314; Klrk1; Nkg2d
- Extra Details:
- Molecular Characterization: hFc(Glu99-Ala330) Mouse NKG2D(Phe90-Val232)Molecular weight: The protein has a predicted molecular mass of 42.6 kDa after removal of the signal peptide. The apparent molecular mass of hFc-mNKG2D is approximately 35-55 kDa due to glycosylation.Description: Recombinant mouse NKG2D protein with N-terminal human Fc tagFunction as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells; leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8( ) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx; culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including RAET1A; RAET1B; RAET1C; RAET1D; RAET1E; H60 and MULT1.[UniProtKB/Swiss-Prot Function]
- Host:
- HEK293
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
