Recombinant Mouse GITR Ligand Protein; hFc Tag
Product Sizes
50 µg
£750.00
32-17956-50UG
100 µg
£911.00
32-17956-100UG
About this Product
- SKU:
- 32-17956
- Additional Names:
- Tnfsf18
- Extra Details:
- Molecular Characterization: hFc(Glu99-Ala330) Mouse GITR Ligand(Thr47-Ser173)Molecular weight: The protein has a predicted molecular mass of 40.6 kDa after removal of the signal peptide. The apparent molecular mass of hFc-mGITRL is approximately 40-55 kDa due to glycosylation.Description: Recombinant mouse GITR Ligand protein with N-terminal human Fc tagCytokine that binds to TNFRSF18/AITR/GITR (PubMed: 14521928; PubMed: 14647196). Regulates T-cell responses (PubMed: 14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed: 14608036; PubMed: 15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed: 14521928; PubMed: 14647196; PubMed: 18178614). Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed: 23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed: 24107315).[UniProtKB/Swiss-Prot Function]
- Host:
- HEK293
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
