Recombinant Mouse SIRP? Protein; His Tag
Product Sizes
50 µg
£750.00
32-17917-50UG
100 µg
£911.00
32-17917-100UG
About this Product
- SKU:
- 32-17917
- Additional Names:
- SHP substrate 1; SHPS-1; Bit; MyD-1 antigen; mSIRP-alpha1; p84; CD172a
- Extra Details:
- Molecular Characterization: Mouse SIRPa(Lys32-Asn373)6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 38.7kDa after removal of the signal peptide. The apparent molecular mass of mSIRPa-His is approximately 55-70 kDa due to glycosylation.Description: Recombinant mouse SIRPa protein with C-terminal6Ã-His tagImmunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6; PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons; neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion; growth factors or insulin. Mediates negative regulation of phagocytosis; mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity).[UniProtKB/Swiss-Prot Function]
- Host:
- HEK293
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
