Recombinant Human RNF43 Protein; hFc Tag
Product Sizes
50 µg
£750.00
32-17892-50UG
100 µg
£911.00
32-17892-100UG
About this Product
- SKU:
- 32-17892
- Additional Names:
- RNF124; SSPCS; URCC
- Extra Details:
- Molecular Characterization: RNF43(Glu43-Tyr197) hFc(Glu99-Ala330)Molecular weight: The protein has a predicted molecular mass of 39.4 kDa after removal of the signal peptide. The apparent molecular mass of RNF43-hFc is approximately 40-70 kDa due to glycosylation.Description: Recombinant human RNF43 protein with C-terminal human Fc tagThe protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain; a protease-associated domain; an ectodomain; and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling; and expression of this gene results in an increase in ubiquitination of frizzled receptors; an alteration in their subcellular distribution; resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells; including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.
- Host:
- HEK293
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
