Recombinant Human ITGA2 & ITGB1 Heterodimer Protein; His Tag & hFc Tag
Product Sizes
50 µg
£649.00
32-17842-50UG
100 µg
£771.00
32-17842-100UG
About this Product
- SKU:
- 32-17842
- Additional Names:
- Integrin alpha 2 beta 1;ITGA2 & ITGB1
- Extra Details:
- Molecular Characterization: ITGA2(Tyr30-Thr1132)6Ã-His tag and ITGB1(Gln21-Asp728) hFc(Glu99-Ala330)Molecular weight: The heterodimer protein has a predicted molecular mass of 121.8 kDa and 104.5 kDa separately after removal of the signal peptide.Description: Recombinant human ITGA2 protein with C-terminal6Ã-His tag and human ITGB1 protein with C-terminal human Fc tagIntegrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin; collagen; collagen C-propeptides; fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens; modulation of collagen and collagenase gene expression; force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2: ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process; integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection.
- Host:
- HEK293
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
