Recombinant Canis lupus familiaris IL18BP Protein; hFc Tag
Product Sizes
50 µg
£1035.00
32-17711-50UG
100 µg
£1366.00
32-17711-100UG
About this Product
- SKU:
- 32-17711
- Additional Names:
- IL18BP; IL18BPa; Tadekinig-alfa
- Extra Details:
- Molecular Characterization: IL18BP(Thr31-Phe192) hFc(Glu99-Ala330)Molecular weight: The protein has a predicted molecular mass of 43.7 kDa after removal of the signal peptide.The apparent molecular mass of dIL18BP-hFc is approximately 55-70 kDa due to glycosylation.Description: Recombinant Canis IL18BP protein with C-terminal human Fc tagInterleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family; including IL1R2; IL1R1; ILRL2 (IL-1Rrp2); and IL1RL1 (T1/ST2); form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated; resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation; which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.
- Host:
- HEK293
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
