Recombinant Cynomolgus IL9 Protein; hFc Tag
Product Sizes
50 µg
£1354.00
32-17710-50UG
100 µg
£1866.00
32-17710-100UG
About this Product
- SKU:
- 32-17710
- Additional Names:
- Interleukin-9; IL-9; Cytokine P40; T-cell growth factor P40
- Extra Details:
- Molecular Characterization: IL9(Arg19-Ile144) hFc(Glu99-Ala330)Molecular weight: The protein has a predicted molecular mass of 40.0 kDa after removal of the signal peptide.Description: Recombinant Cynomolgus IL9 protein with C-terminal human Fc tagInterleukin 9; also known as IL-9; is a cytokine (cell signaling molecule) belonging to the group of interleukins. IL-9 is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL-9R); which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. IL-9 is a key molecule that affects the differentiation of TH17 cells and Treg function. IL-9 predominantly produced by TH17 cells synergizes with TGF-ÃŽ²1 to differentiate naive CD4 T cells into TH17 cells; while IL-9 secretion by TH17 cells is regulated by IL-23. Interestingly; IL-9 enhances the suppressive functions of FoxP3 CD4 Treg cells in vitro; and the absence of IL-9 signaling weakens the suppressive activity of nTregs in vivo; leading to an increase in effector cells and worsening of experimental autoimmune encephalomyelitis. The mechanism of IL-9 effects on TH17 and Tregs is through activation of STAT3 and STAT5 signaling. Our findings highlight the role of IL-9 as a regulator of pathogenic versus protective mechanisms of immune responses.
- Host:
- HEK293
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
