Recombinant Human MMP2 Protein; His Tag
Product Sizes
50 µg
£805.00
32-17585-50UG
100 µg
£994.00
32-17585-100UG
About this Product
- SKU:
- 32-17585
- Additional Names:
- CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1
- Extra Details:
- Molecular Characterization: MMP2(Ala30-Cys660)6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 71.8 kDa after removal of the signal peptide.The apparent molecular mass of MMP2-His is approximately 55-70 kDa due to glycosylation.Description: Recombinant human MMP2 protein with C-terminal6Ã-His tagThis gene is a member of the matrix metalloproteinase (MMP) gene family; that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A; type IV collagenase; that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members; activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases; or; intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system; endometrial menstrual breakdown; regulation of vascularization; and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
- Host:
- HEK293
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Assay Kits:MMP
- Manufacturer's Data Sheet:download_pdf.php
