Recombinant human IL12RB1 protein with C-terminal human Fc tag
Product Sizes
50 µg
£823.00
32-17240-50UG
About this Product
- SKU:
- 32-17240
- Additional Names:
- CD212;IL-12R-BETA1;IL12RB;IMD30
- Extra Details:
- Expression Host : HEK293 The protein has a predicted molecular mass of 82.94 kDa after removal of the signal peptide. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity; and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer; which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
- Purification:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -80[o]C for 12 months (Avoid repeated freezing and thawing)
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
