Recombinant human IL10 protein with C-terminal human Fc tag
Product Sizes
50 µg
£805.00
32-17238-50UG
About this Product
- SKU:
- 32-17238
- Additional Names:
- CSIF;GVHDS;IL-10;IL10A;TGIF
- Extra Details:
- Expression Host : HEK293 The protein has a predicted molecular mass of 43.12 kDa after removal of the signal peptide. The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines; MHC class II Ags; and costimulatory molecules on macrophages. It also enhances B cell survival; proliferation; and antibody production. This cytokine can block NF-kappa B activity; and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
- Purification:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -80[o]C for 12 months (Avoid repeated freezing and thawing)
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
