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Recombinant human CTLA-4 protein with C-terminal human Fc tag

Product Sizes
50 µg
£706.00
32-17091-50UG
About this Product
SKU:
32-17091
Additional Names:
CTLA4; CD152
Extra Details:
Expression Host : HEK293 The protein has a predicted molecular mass of 39.6 kDa after removal of the signal peptide.The apparent molecular mass of CTLA4-hFC is approximately 40-55 kDa due to glycosylation. This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain; a transmembrane domain; and a cytoplasmic tail. Alternate transcriptional splice variants; encoding different isoforms; have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond; while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus; Graves disease; Hashimoto thyroiditis; celiac disease; systemic lupus erythematosus; thyroid-associated orbitopathy; and other autoimmune diseases.
Purification:
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at -80[o]C for 12 months (Avoid repeated freezing and thawing)
Supplier:
Abeomics
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules
  • Manufacturer's Data Sheet:1.jpg
Figure 2. ELISA plate pre-coated by 2 µg/ml (100 µl/well) Human CTLA-4; hFc tagged protein can bind Anti-CTLA4 Neutralizing antibody in a linear range of 0.64-80.0 ng/ml.
Figure 3. HEK293 cell line transfected with irrelevant protein (B) and human B7-2 (A) were surface stained with Human CTLA4; hFc tagged protein 1µg/ml followed by Alexa 488-conjugated anti-human IgG secondary antibody.
Figure 3. HEK293 cell line transfected with irrelevant protein (B) and human B7-2 (A) were surface stained with Human CTLA4; hFc tagged protein 1µg/ml followed by Alexa 488-conjugated anti-human IgG secondary antibody.