Recombinant human SIRP alpha protein with C-terminal human Fc and6Ã-His tag
Product Sizes
50 µg
£688.00
32-17009-50UG
About this Product
- SKU:
- 32-17009
- Additional Names:
- SHPS1; SIRPA; CD172A; BIT; MFR; MYD1; P84; PTPNS
- Extra Details:
- Expression Host : HEK293 The protein has a predicted molecular mass of 70-98 kDa after removal of the signal peptide. Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a); Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84; is a member of the SIRP family; and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6;PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons; neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion; growth factors or insulin and mediates negative regulation of phagocytosis; mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
- Purification:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -80[o]C for 12 months (Avoid repeated freezing and thawing)
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
