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Recombinant human CD47 protein with C-terminal mouse Fc and6Ã-His tag

Product Sizes
50 µg
£688.00
32-17008-50UG
About this Product
SKU:
32-17008
Additional Names:
CD47; MER6; IAP; OA3
Extra Details:
Expression Host : HEK293 The protein has a predicted molecular mass of 60 kDa after removal of the signal peptide. Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3; Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets; and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA; binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion; enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
Purification:
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at -80[o]C for 12 months (Avoid repeated freezing and thawing)
Supplier:
Abeomics
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules
  • Manufacturer's Data Sheet:1.jpg
Figure 2. ELISA plate pre-coated by 2 µg/ml (100 µl/well) Human CD47; mFc-His tagged protein can bind its native ligand Human SIRP alpha; hFc-His tagged protein in a linear range of 3.3-26.37 ng/ml.
Figure 3. ELISA plate pre-coated by 2 µg/ml (100 µl/well) Human CD47; mFc-His tagged protein can bind Anti-CD47 (Neutralizing antibody clone Hu5F9-G4) in a linear range of 0.061-1.606 ng/ml.
Figure 3. ELISA plate pre-coated by 2 µg/ml (100 µl/well) Human CD47; mFc-His tagged protein can bind Anti-CD47 (Neutralizing antibody clone Hu5F9-G4) in a linear range of 0.061-1.606 ng/ml.