Recombinant human FLT3 protein with C-terminal human Fc and6Ã-His tag
Product Sizes
50 µg
£688.00
32-17007-50UG
About this Product
- SKU:
- 32-17007
- Additional Names:
- Flt-3; Flk-2; STK-1; CD135; FLK2; FLT-3
- Extra Details:
- Expression Host : HEK293 The protein has a predicted molecular mass of 125-130 kDa after removal of the signal peptide. Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2); STK-1(Stem cell tyrosine kinase 1); CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation; proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1; and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases; including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
- Purification:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -80[o]C for 12 months (Avoid repeated freezing and thawing)
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
