IL 28A His Recombinant Protein
Product Sizes
10 µg
£528.00
32-1506-10UG
About this Product
- SKU:
- 32-1506
- Additional Names:
- Interleukin-28A||IL-28A||IFN-Lambda 2||Interferon-Lambda 2||Cytokine ZCYTO20||IL28A||IFNL2||ZCYTO20.
- Extra Details:
- Source : Escherichia Coli. IL 28A Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 198 amino acids (26-200 a.a.) and having a molecular mass of 22.1kDa. IL 28A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. IL-28A is distantly related to type I interferons and the IL-10 family. Expression of IL-28A is induced by viral infection which interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor; beta (IL10RB) and interleukin 28 receptor; alpha. IL-28A exhibits common features with type I IFNs such as antiviral activity; antiproliferative activity and in vivo antitumour activity.IL-28A acts similarly to IFNs; but is less effective generally and has activity in a more limited range of cell lines. IFN-ambda 1; IFN-lambda 2 and IFN-lambda 3 are closely positioned genes on human chromosome 19.IL-28A induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells; in an IFN-gamma-independent manner. IL-28A is able to generate tolerogenic DCs; an activity that could thwart IFN-beta functions. IL-28A produced in response to viral infection; activates both monocytes and macrophages producing a restricted panel of cytokines and therefore is an important factor in activating innate immune responses at the site of viral infection.
- Purification:
- Greater than 85% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
