IL 27 Recombinant Protein
Product Sizes
5 µg
£528.00
32-1501-5UG
About this Product
- SKU:
- 32-1501
- Additional Names:
- Interleukin-30||IL-30||IL-27/p28||p28||Interleukin-27||Interleukin-27/p28||IL-27||Interleukin-27 subunit alpha||IL-27 subunit alpha||IL27-A||Il27||Il27a||IL-27p28.
- Extra Details:
- Source : HEK. IL-27 Human Recombinant produced in HEK cells is a glycosylated heterodimer; having a molecular weight range of 25-30kDa due to glycosylation.The IL-27 is purified by proprietary chromatographic techniques. Interleukin-27 protein is related to IL-12A & is one of the subunits of a heterodimeric cytokine complex. IL-27 interacts with EBV induced gene 3 also called EBI3; and forms a complex that drives rapid expansion of CD4 (+) T cells. IL-27 complex is synergizes with IL-12 in order to trigger the cytokine production of IFN-Gamma of CD4 (+) T cells. The biological effect of IL-27 is mediated by class-I cytokine receptor (WSX1/TCRR). The pro-inflammatory activity of IL-27 is mediated through the growing expression of key molecules involved in the MHC class-I & MHC class-II pathways. Both MHC class-I and MHC-class-II expression are increased in endothelial cells after Interleukin-27 stimulation which suggests that it may play an important role in conferring the immune function on vascular endothelium IL-27p28 subunit can be induced by IFN-beta and during LPS-induced maturation of dendritic cells in type-I IFN-dependent manner through IFN regulatory factor-1 activation. Interleukin-27 regulates Interleukin-12 responsiveness of CD4+ T cells through Stat1-dependent and -independent mechanisms. IL-17 & IL-23 play an important IL-17 role in inflammation. Interleukin-27 possesses potent anti-angiogenic activity that plays an important role in its antitumor and antimetastatic activities. EBV induced gene 3 plays a role; independently from IL-27; in regulating anti-viral or anti-tumoral immune responses. Interleukin-27 is a potent inhibitor of HIV-1 replication in macrophages; CD4+ T cells; peripheral blood mononuclear cells. Interleukin-27 triggers STAT activation and gene transcription.
- Purification:
- Greater than 90% as obsereved by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Lyophilized IL-27 although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution IL27 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
