SIRPA Human; HEK
Product Sizes
2 µg
£452.00
32-13800-2UG
10 µg
£528.00
32-13800-10UG
About this Product
- SKU:
- 32-13800
- Additional Names:
- Tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1; SHP substrate 1; SHPS-1; Brain Iglike molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; MYD1; PTPNS1; SHPS1;SIRP; Inhibitory receptorSHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-
- Extra Details:
- Source:HEK293 Cells.Physical Appearance:Sterile Filtered clear solution.Biological ActivityMeasured by its binding ability in a functional ELISA with Human CD47.Signal-Regulatory Protein Alpha; SIRPA belongs to the signal-regulatory-protein (SIRP) family; as well as the immunoglobulin super family. The members of the SIRP family are receptor-type transmembrane glycoproteins which are involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. SIRPA can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP); and perform as substrates of PTPs. SIRPA take part in signal transduction mediated by a variety of growth factor receptors. CD47 has been shown to be a ligand for SIRPA.SIRPA Human Recombinant produced in HEK293 cells is a single; glycosylated polypeptide chain (27-373a.a) containing 356 amino acids and having a molecular mass of 39kDa.SIRPA is fused to a 6 amino acid His-tag at C-terminus;and is purified by proprietary chromatographic techniques.
- Format:
- The SIRPA solution (1mg/ml) contains Phosphate-Buffered Saline (pH 7.4) and 10% glycerol.
- Purification:
- Greater than 95% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
