CFH Human
Product Sizes
20 µg
£600.00
32-13752-20UG
100 µg
£1030.00
32-13752-100UG
About this Product
- SKU:
- 32-13752
- Additional Names:
- Complement factor H; H factor 1; CFH; HF; HF1; HF2.
- Extra Details:
- Source:Human Plasma.Physical Appearance:Sterile filtered solution.Biological ActivitynullComplement factor H (CFH) is an important regulatory component of the alternative pathway of complement. CFH is prevents complement activation on host cells and tissues; mainly the kidney. CFH controls the formation and decay of the alternative pathway C3/C5 convertase and acts as a cofactor for factor I which proteolytically inactivates C3b when C3b is bound to factor H. The N-terminal 5 domains of CFH bind to C3b and inhibit binding of factor B thus reducing the formation of C3/C5 convertase. CFH also binds to preformed C3/C5 convertases and causes quick release of the catalytic subunit Bb. These activities are necessary for controlling the spontaneous activation of the alternative pathway amplification process in plasma. In addition; CFH controls the formation and decay of these enzymes when C3b is attached to the surface of particles.Human Complement Factor H produced in Human plasma having a total molecular mass of 155kDa.
- Format:
- CFH protein solution contains 10mM Sodium phosphate and 145mM NaCl; pH 7.3.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- CFH Human is stable at 4[o]C if entire vial will be used within 2-4 weeks.Store; frozen below -20[o]C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
