CHIKV E2
Product Sizes
100 µg
£547.00
32-13620-100UG
0.5 mg
£1030.00
32-13620-0.5MG
About this Product
- SKU:
- 32-13620
- Additional Names:
- Chikungunya is an infection caused by the chikungunya virus which is passed to humans by two species of mosquito of the genus Aedes: A. albopictus and A. aegypti. Animal reservoirs of the virus include monkeys; birds; cattle; and rodents. The features of the disease are a sudden onset of fever 2-4
- Extra Details:
- Source: Escherichia Coli.Sterile filtered colorless solution.Chikungunya is an infection caused by the chikungunya virus which is passed to humans by two species of mosquito of the genus Aedes: A. albopictus and A. aegypti. Animal reservoirs of the virus include monkeys; birds; cattle; and rodents. The features of the disease are a sudden onset of fever 2-4 days after exposure. The fever typically lasts 2-7 days; while the associated joint pains usually last weeks or months but sometimes years. The mortality rate is a little less than 1 in 1;000. The disease has occurred in outbreaks in Asia; Europe and the Americas since 2004. CHIKV is a single-stranded positive-sense RNA genome; 11;800 nts long which encodes 2 open reading frames. The nucleocapsid is tightly enveloped by a host-derived lipid bilayer (envelope) supporting the virus-encoded envelope proteins. 80 glycoprotein spikes are C- terminally anchored within the viral envelope. The structural polyprotein is translated from a viral sub genomic mRNA; while as the 5 structural proteins (capsid; E3; E2; 6K; E1) are translated as a single polyprotein; from which capsid (C) is cleaved off to encapsidate. The envelope polyprotein precursor E3-E2-6K-E1 is translocated to the endoplasmatic reticulum. Polyprotein is processed by host signalases; resulting in E3; E2 & E1 forming viral hetero-trimeric spikes. The viral spikes majorly contains E2 and E1 facilitate cell receptor recognition; cell entry thru pH-dependent endocytosis and support viral budding.Recombinant Chikungunya E2 produced in E.coli having a molecular weight of 38kDa (migrates at 38-40kDa on 10% SDS-PAGE).
- Purification:
- Protein is >95% pure as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- CHIKV E2 although stable at 4[o]C for 1 week; should be stored below -18[o]C. Please prevent freeze thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
