Norovirus Group-2 P-Domain
Product Sizes
100 µg
£547.00
32-13618-100UG
0.5 mg
£1030.00
32-13618-0.5MG
About this Product
- SKU:
- 32-13618
- Additional Names:
- Human norovirus is classified into two groups; group 1& group 2. Norwalk virus is the species which belongs to group 1 and was discovered in 1968 at Ohio. Norovirus is a familiar virus which causes human gastroenteritis with the following symptoms vomiting; diarrhea and sickness. CDC report revea
- Extra Details:
- Source: Escherichia Coli.Sterile Filtered clear solution.Human norovirus is classified into two groups; group 1& group 2. Norwalk virus is the species which belongs to group 1 and was discovered in 1968 at Ohio. Norovirus is a familiar virus which causes human gastroenteritis with the following symptoms vomiting; diarrhea and sickness. CDC report revealed that there are 19-21 million Americans infected by Nororvirus annually with 800 deaths; 1 in 15 people with infection. Around the world; this virus affects about 267 million people and causes over 200;000 deaths each year; these losses are mostly in less developed countries and in the very young; elderly and immuno-suppressed population; though; most cases are self-limited with a full recovery within just a few days. Norovirus is extremely contagious and can spread from human to human through infected food; water or contaminated surfaces. The outbreaks usually occur from November-April; while the peak is in January. Norovirus is a positive sense RNA virus with 7.5 kb nucleotides; encoding a major structural protein VP1 with 50-55kDa. The full length of VP1 capsid comprises the internal N-terminal; Hinge; shell (S) and protruding (P) domains. P domain from 225 to 520 forms P1- P2-P1 structure. Moreover; P domain has a receptor binding region which recognizes human histo-blood group antigens (HBGAs). P domain expressed in bacteria can spontaneously form a P dime as well as a P particle aggregated by 12 P dimmers. P particle displays an increased binding activity to HBGAs higher than virus-like particle (VLP) formed by the full-length capsid. For norovirus vaccine development; we consider P domain as a good candidate.The Recombinant Norovirus Group-2 Capsid P-Domain; E.Coli derived; VA387 Strain contains a.a. from 225-520 having a Mw of 30kDa. The protein is fused to a 6xHis tag at N-terminal and purified by chromatography techniques. P-domain (225-520 a.a.) forms P1- P2-P1 structure. P-domain has a receptor binding region to recognize human histo-blood group antigens (HBGAs). P-domain expressed in bacteria can spontaneously form a P dime and a P particle aggregated by 12 P dimmers. P-particle displays an enhanced binding activity to HBGAs higher than virus-like particle (VLP) formed by the full length capsid.
- Purification:
- Protein is >95% pure as determined by 12% PAGE (coomassie staining).
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The Recombinant Norovirus Group-2 P-Domain although stable at 4[o]C for 1 week; should be stored below -18[o]C. Please prevent freeze thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Viral Particles
- Manufacturer's Data Sheet:download_pdf.php
