CD163 Human
Product Sizes
1 µg
£452.00
32-13357-1UG
5 µg
£528.00
32-13357-5UG
About this Product
- SKU:
- 32-13357
- Additional Names:
- CD163 Molecule; Hemoglobin Scavenger Receptor; CD163 Antigen; M130; Scavenger Receptor Cysteine-Rich Type 1 Protein M130; Macrophage-Associated Antigen; SCARI1; MM130;CD163.
- Extra Details:
- Source: Sf9; Baculovirus cells.Sterile Filtered colorless solution.CD163 is an acute phase-regulated receptor which participates in the removal and endocytosis of hemoglobin/haptoglobin complexes by macrophages and thus keeps tissues from free hemoglobin-mediated oxidative damage. Furthermore; CD163 partakes in the uptake and recycling of iron; through endocytosis of hemoglobin/haptoglobin and ensuing breakdown of heme. In addition; CD163 binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent way. CD163 demonstrates greater affinity for complexes of hemoglobin and multimeric haptoglobin of HP-1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP-1S phenotype. Moreover; CD163 stimulates a cascade of intracellular signals which involves tyrosine kinase-dependent calcium recruitment; inositol triphosphate formation and secretion of IL-6 & CSF-1.CD163 produced in Sf9 Baculovirus cells is a single; glycosylated polypeptide chain containing 1015 amino acids (42-1050a.a.) and having a molecular mass of 109.8kDa. (Molecular size on SDS-PAGE will appear at approximately 100kDa). CD163 is expressed with an 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
