LY9 Human
Product Sizes
1 µg
£452.00
32-13307-1UG
5 µg
£528.00
32-13307-5UG
About this Product
- SKU:
- 32-13307
- Additional Names:
- Lymphocyte Antigen 9; Signaling Lymphocytic Activation Molecule 3; Cell Surface Molecule Ly-9; SLAM Family Member 3; SLAMF3; CD229 Antigen; CD229; Hly9; MLY9; LY9.
- Extra Details:
- Source: Sf9; Baculovirus cells.Sterile filtered colorless solution.Lymphocyte Antigen 9; also known as LY9 is a member of the SLAM family of immunomodulatory receptors; LY9 interacts with the adaptor molecule SAP . LY9 plays a part in adhesion reactions between T lymphocytes and accessory cells via homophilic interaction. LY9 promotes T-cell differentiation into a helper T-cell Th17 phenotype which leads to increased IL-17 secretion; the costimulatory activity requires SH2D1A. Furthermore it also promotes recruitment of RORC to the IL-17 promoter. LY9 is implicated in the maintenance of peripheral cell tolerance through serving as a negative regulator of the immune response. LY9 disables autoantibody responses as well as inhibits IFN-gamma secretion by CD4(+) T-cells. Moreover; LY9 negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells. Systemic Lupus Erythematosus is one of the diseases which are associated with LY9. LY9 Human Recombinant produced in Sf9 Baculovirus cells is a single; glycosylated polypeptide chain containing 416 amino acids (48-454 aa) and having a molecular mass of 45.9kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).LY9 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
