L-Selectin Human; Sf9
Product Sizes
2 µg
£452.00
32-13303-2UG
10 µg
£528.00
32-13303-10UG
About this Product
- SKU:
- 32-13303
- Additional Names:
- Selectin L; Leukocyte-Endothelial Cell Adhesion Molecule 1; CD62 Antigen-Like Family Member L; Leukocyte Surface Antigen Leu-8; Lymphocyte Adhesion Molecule 1; Lymph Node Homing Receptor; Gp90-MEL; LECAM1; LYAM1; LNHR; TQ1; Leukocyte Adhesion Molecule; Pln Homing Receptor; CD62L Antigen; L-Selectin
- Extra Details:
- Source: Sf9; Baculovirus cells.Sterile Filtered clear solution.L-Selectin belongs to a family of divalent cation-dependent carbohydrate-binding glycoproteins or adhesion molecules. The L-Selectin molecule is composed of various domains: one homologous to lectins; one to epidermal growth factor; and two to the consensus repeat units found in C3/C4 binding proteins.L-selectin is expressed constitutively on lymphocytes; monocytes and granulocytes and interacts specifically with carbohydrate groups on activated endothelial cells. L-Selectin may be shed by proteolytic cleavage and circulating levels in biological fluids may be used as an indicator of various pathological conditions. L-Selectin is cleaved by ADAM17.L-selectin works as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via the high endothelial venules. Ligands present on endothelial cells will attach to leukocytes expressing L-selectin; which causes the leukocytes to become localized at that juncture. The receptor is also located on the cell surfaces of "naive" T cells; which have not yet encountered their particular antigen. This surface expression is lost following the cells activation.L-Selectin produced in Sf9 Baculovirus cells is a single; glycosylated polypeptide chain containing 303 amino acids (52-345a.a.) and having a molecular mass of 34.1kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).L-Selectin is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
- Purification:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Lectins
- Manufacturer's Data Sheet:download_pdf.php
