LINGO1 Human
Product Sizes
5 µg
£452.00
32-13297-5UG
20 µg
£528.00
32-13297-20UG
About this Product
- SKU:
- 32-13297
- Additional Names:
- Leucine Rich Repeat And Ig Domain Containing 1; LRRN6A; Leucine-Rich Repeat And Immunoglobulin Domain-Containing Protein 1; Leucine-Rich Repeat Neuronal Protein 1; Leucine Rich Repeat Neuronal 6A; LERN1; Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein
- Extra Details:
- Source: Escherichia Coli.Sterile Filtered colorless solution.Leucine Rich Repeat And Ig Domain Containing 1; also known as Lingo1 is primarily expressed in neuronal tissue; and most abundantly in the cortex. In addition; Lingo 1 is involved in the inhibition of axon regeneration all the way through a ternary complex formed with NgR1 (ligand-binding subunit) and p75 (signal transducing subunit). The inhibitory action is accomplished through RhoA-GTP upregulation in response to the presence of MOG; MAG or Nogo-66 in the central nervous system. Furthermore; LINGO-1 inhibits oligodendrocyte precursor differentiation as well as myelination; by a mechanism which also involves activation of RhoA; however it appears that it does not require 75 or NgR1.LINGO1 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 133 amino acids (241-337 a.a) and having a molecular mass of 15.1kDa. LINGO1 is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
