LA/SS-B Human; Biotin
Product Sizes
50 µg
£968.00
32-13286-50UG
100 µg
£1255.00
32-13286-100UG
About this Product
- SKU:
- 32-13286
- Additional Names:
- Lupus La protein; Sjoegren syndrome type B antigen; SS-B; La ribonucleoprotein; La autoantigen; SSB; La; LARP3; LA/SS-B; La(SS-B).
- Extra Details:
- Source: Sf9 insect cells.Sterile Filtered clear solution.The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjogren's syndrome patients. La is involved in various aspects of RNA metabolism; including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III - transcribed RNA; processing 5-prime and 3-prime ends of pre-tRNA precursors; acting as an RNA chaperone; and binding viral RNAs linked to hepatitis C virus. It occurs in both the nucleus and the cytoplasm; where it assumes different roles. In the nucleus; La protein facilitates the production of tRNAs; acting as an RNA polymerase III (RNAP III) transcription factor by attaching to the U-rich 3'UTR of nascent transcripts; aiding in their folding and maturation. In the cytoplasm; La protein facilitates the translation of specific mRNAs; acting as a translation factor. As an RNA binding protein (RBP); La protein associates with subsets of mRNAs which contain a 5'-terminal oligopyrimidine (5'TOP) motif known to direct protein synthesis. The binding of La protein to particular classes of RNA molecules regulates their downstream processing; guards them from endonuclease digestion; and organizes their export from the nucleus. La/SS-B appears to be readily disposed to proteolysis; which results in many smaller (42kD; 320; and 270) nevertheless still immunoreactive polypeptides. La/SS-B antigen is strongly conserved across species. Anti-La/SS-B autoantibodies were originally found as precipitating autoantibodies in sera of Sjogren's Syndrome patients and referred to as SjT. Anti-La/SS-B precipitins are most frequently found in Sjogren's Syndrome; Systemic Lupus Erythematosus (SLE) and Subacute Cutaneous Lupus. Also; there seems to be a correlation between anti-La/SS-B and the absence of nephritis in SLE patients.LA/SS-B Human Recombinant produced in SF9 is a single; glycosylated; polypeptide chain having a calculated molecular mass of 48 kDa. The LA/SS-B is expressed with a -6x His tag at N-terminus and purified by proprietary chromatographic techniques.
- Purification:
- Greater than 80.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
