F3 Mouse
Product Sizes
2 µg
£452.00
32-13222-2UG
10 µg
£528.00
32-13222-10UG
About this Product
- SKU:
- 32-13222
- Additional Names:
- Tissue factor; TF; Coagulation factor III; CD142.
- Extra Details:
- Source: Sf9; Baculovirus cells.Sterile Filtered colorless solution.Tissue factor is well-known as the main cellular initiator of blood coagulation. The Tissue factor gene encodes coagulation factor III which is a cell surface glycoprotein that enables cells to initiate the blood coagulation cascades; and functions as the high-affinity receptor for the coagulation factor VII. Following vessel injury; the Tissue Factor and Factor VIIa complex activates the coagulation protease cascade; which leads to fibrin deposition and activation of platelets. The ensuing complex presents a catalytic event; which is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Therefore; Tissue factor has a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Tissue Factor can also be stimulated by the inflammatory mediators interleukin 1 and TNF; as well as by endotoxin; to appear on monocytes and vascular endothelial cells as a component of cellular immune response.Tissue factor is the only one in the coagulation pathway for which a congenital deficiency has not been described. Certain levels of Tissue Factor are essential for the maintained viability and growth of endothelium and Tissue Factor-expressing tumor cells. Additionally; abnormal Tissue Factor expression inside the vasculature initiates life threatening thrombosis in various diseases; for example sepsis; atherosclerosis; and cancer. Alternative spliced Tissue Factor expression advances tumor growth; and is linked to increased tumor cell proliferation and angiogenesis in pancreatic cancer.F3 produced in Sf9 Baculovirus cells is a single; glycosylated polypeptide chain containing 232 amino acids (29-251 a.a.) and having a molecular mass of 26.4kDa (Migrates at 28-40kDa on SDS-PAGE under reducing conditions).
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
