EDA2R Human; Sf9
Product Sizes
2 µg
£452.00
32-13200-2UG
10 µg
£528.00
32-13200-10UG
About this Product
- SKU:
- 32-13200
- Additional Names:
- Tumor necrosis factor receptor superfamily member 27; X-linked ectodysplasin-A2 receptor; EDA-A2 receptor; Ectodysplasin A2 Receptor; X-Linked Ectodysplasin-A2 Receptor; EDA-A2 Receptor; TNFRSF27; XEDAR; Tumor Necrosis Factor Receptor Superfamily Member XEDAR; Tumor Necrosis Factor Receptor Superfa
- Extra Details:
- Source: Sf9; Baculovirus cells.Sterile Filtered clear solution.EDA2R (ectodysplasin A2 receptor) mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated through binding to TRAF3 and TRAF6. In addition; Mutations in EDA give rise to a clinical syndrome characterized by loss of hair; sweat glands; and teeth. EDA2R specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily; and contains 3 cysteine-rich repeats and a single transmembrane domain however it lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene. Among the diseases associated with EDA2R are ectodermal dysplasia 1; hypohidrotic; x-linked; and hypohidrotic ectodermal dysplasia.EDA2R Human Recombinant produced in Sf9 Baculovirus cells is a single; glycosylated polypeptide chain containing 380 amino acids (1-138a.a.) and having a molecular mass of 42.5kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). EDA2R is expressed with a 242 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
