TGFBR2 Human; His
Product Sizes
2 µg
£452.00
32-13010-2UG
10 µg
£528.00
32-13010-10UG
About this Product
- SKU:
- 32-13010
- Additional Names:
- AAT3; FAA3; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGFBR-2; TGF-beta receptor type-2; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TGF-beta type II receptor; TbetaR-II; TGFBR2.
- Extra Details:
- Source: Sf9; Baculovirus cells.Sterile Filtered colorless solution.TGFBR2 is part of the Ser/Thr protein kinase family and the TGFB receptor subfamily. TGFBR2 is a transmembrane protein that has a protein kinase domain; forms a heterodimeric complex with another receptor protein; and binds TGF-beta. This receptor/ligand complex phosphorylates proteins; which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome; Loeys-Deitz Aortic Aneurysm Syndrome; and the development of various types of tumors. TGFBR2 expression is increased in oral squamous cell carcinoma cells. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity of tamoxifen metabolites in breast cancer.TGFBR2 Human Recombinant produced in in Sf9 Baculovirus cells is a single; non-glycosylated polypeptide chain containing 383 amino acids (23-166a.a) and having a molecular mass of 43.3kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions). TGFBR2 is expressed with a 239aa hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
- Purification:
- Greater than 95% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
