GMF b Recombinant Protein
Product Sizes
10 µg
£528.00
32-1293-10UG
About this Product
- SKU:
- 32-1293
- Additional Names:
- Glia maturation factor beta||GMFB||GMF-B||GMF-beta||GMF.
- Extra Details:
- Source : Escherichia Coli. Glia Maturation Factor-Beta (GMF-Beta) Human Recombinant produced in E.Coli is a signle; non-glycosylated; polypeptide chain containing 141 amino acids and having a total molecular mass of 16.5 kDa. Glia Maturation Factor-Beta; GMF-Beta; Human Recombinant is purified by proprietary chromatographic techniques. Glia Maturation Factor-Beta (GMF-Beta) is a 17 kDa protein nerve gorwth factor identified as a growth and differentiation factor in the vertebrate brain.Glia Maturation Factor-Beta stimulates differentiation of normal neurons as well as glial cells. GMFB inhibits the proliferation of the N-18 neuroblastoma line and the C6 glioma line while promoting their phenotypic expression.GMF-beta inhances the phenotypic expression of glia & neurons thus inhibits the proliferation of their respective tumors when added to cell culture. Although astrocytes produce GMF-b and stores it inside the cells; they don't secrete the GMF-B into the cultured medium. Cell- surface GMFb acts on the target cells at close range when cells are in direct contact. GMF-Beta is produced by thymic epithelial cells and plays an important role in T cell development in favor of CD4+ T cells.GMF-Beta is a brain-specific protein which belongs to the actin-binding proteins (ADF) family. GMF-beta appears to play a role in the differentiation; maintenance; and regeneration of the nervous system. It also supports the progression of certain auto-immune diseases; possibly through its ability to induce the production and secretion of various pro-inflammatory cytokines.
- Purification:
- Greater than 98.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Lyophilized GMF-B although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution GMF-beta should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
