Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-6His)
Product Sizes
10 µg
£468.00
32-11207-10UG
50 µg
£606.00
32-11207-50UG
About this Product
- SKU:
- 32-11207
- Additional Names:
- Dickkopf-related protein 1;Dickkopf-1;Dkk-1
- Extra Details:
- Mammalian Cells Dickkopf-related protein 1(DKK-1); is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development; where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning; limb development; somitogenesis and eye formation. In the adult; Dkks are implicated in bone formation and bone disease; cancer and Alzheimer disease.
- Host:
- Human
- Shipping Conditions:
- Blue Ice
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:DKK1.jpg
