Anti-Human CD38 Monoclonal Antibody PE Conjugated (Clone: HB7)
Product Sizes
100 tests
£605.00
30-2942PE-100TESTS
About this Product
- SKU:
- 30-2942PE
- Additional Names:
- ADPRC1; cADPr hydrolase 1; T10; NAD(+) nucleosidase; ADP-ribosyl cyclase 1
- translate.label.attr.clone:
- HB7
- Clonality:
- Monoclonal
- Conjugate:
- PE
- Extra Details:
- Specificity: The mouse monoclonal antibody HB7 (HB-7) recognizes an extracellular epitope within amino acids 273-285 of human CD38; a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes; it is an antigenic marker of lymphoid cells. Its binding is blocked by daratumumab. Background: CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation; proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose; as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase; thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration. CD38 belongs to markers of B cell subsets; leukemia; and a target of immunotherapy in myeloma treatment. CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation; proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose; as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase; thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration. CD38 belongs to markers of B cell subsets; leukemia; and a target of immunotherapy in myeloma treatment.
- Host:
- Mouse
- Immunogen:
- BJAB cell line
- Isotype:
- Mouse IgG1 kappa
- Purification:
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
