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Antibodies

Anti-Human CX3CR1 Monoclonal Antibody (Clone:2A9-1) Biotin Conjugated

Product Sizes
0.1 mg
£581.00
30-2935-B-0.1MG
About this Product
SKU:
30-2935-B
Additional Names:
V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1; fractalkine receptor
translate.label.attr.clone:
2A9-1
Clonality:
Monoclonal
Conjugate:
Biotin
Extra Details:
Specificity: The rat monoclonal antibody 2A9-1 recognizes an extracellular epitope of CX3CR1; an important regulator of leukocyte trafficking and immune system ballance. Description: CX3CR1 (fractalkine receptor) serves as a regulator of leukocyte trafficking. Its ligand CX3CL1 (fractalkine) can serve bots as chemoatractant (soluble) and as adhesive molecule (membrane bound). Binding to the cell surface expressed ligand leads to rapid induction of firm adhesion of CX3CR1-positive cells without requiring selectin-mediated rolling or activation of integrins. This interaction is important for trafficking of cytotoxic effector lymphocytes regardless of their lineage and mode of target cell recognition; through inflamed endothelium. Similarly; it mediates monocyte/macrophage recruitment to inflamed atherosclerotic plaques; as well as in their homing to non-inflamed tissues; where they can differentiate into dendritic cells. CX3CR1 also promotes cell survival; plays a key role in brain microglia; synapse maturation and regulation of inflammatory response in the central nervous system; it acts as a negative regulator of angiogenesis; and serves as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi.
Host:
Rat
Immunogen:
Human CX3CR1 transfectants
Isotype:
Rat IgG2b kappa
Purification:
Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at 2-8[o]C. Do not freeze.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
Fig 2: Flow cytometry multicolor surface staining pattern of human peripheral whole blood stained using anti-human CD3 (UCHT1) PE antibody (20 μl reagent / 100 μl of peripheral whole blood) and anti-human CX3XR1 (2A9-1) biotin antibody (concentration in sample 5μg/ml; Streptavidin APC).
Fig 3: Separation of human monocytes (red-filled) from CD3 positive CX3CR1 negative T cells (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CX3XR1 (2A9-1) biotin antibody (concentration in sample 5μg/ml; Streptavidin APC).
Fig 3: Separation of human monocytes (red-filled) from CD3 positive CX3CR1 negative T cells (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CX3XR1 (2A9-1) biotin antibody (concentration in sample 5μg/ml; Streptavidin APC).