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Antibodies

PE Anti-CD207 Monoclonal Antibody (Clone:2G3)

Product Sizes
100 tests
£649.00
30-2927PE-100TESTS
About this Product
SKU:
30-2927PE
translate.label.attr.clone:
2G3
Clonality:
Monoclonal
Conjugate:
PE
Extra Details:
CD207 is a 40 kDa type II transmembrane glycoprotein of the C-type lectin family. It binds to mannose-bearing glycoproteins and glycolipids of microbial and viral antigens; including HIV gp120. CD207 is expressed only in Langerhans cells; which are immature dendritic cells of the epidermis and mucosa; and its expression decreases during Langerhans cells maturation. Upon antigen binding CD207 localizes to the Birbeck granules; organelles present in the cytoplasm of Langerhans cells and consisting of superimposed membranes; which leads to a nonclassical antigen-processing pathway.
Host:
Mouse
Immunogen:
Fusion protein of human CD207 extracellular part and IgG Fc fragment
Isotype:
Mouse IgG1 lambda
Purification:
Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Figure 2: Flow cytometry multicolor surface staining pattern of human stimulated (GM-CSF + IL-4) peripheral blood mononuclear cells stained using anti-human CD207 (2G3) PE antibody (10 μl reagent per milion cells in 100 μl of cell suspension) and anti-human CD11c (BU15) APC antibody (10 μl reagent per milion cells in 100 μl of cell suspension).
Figure 3: Separation of human CD207 positive CD11c positive dendritic cells differentiated upon monocyte stimulation (GM-CSF + IL-4) (red-filled) from non-stimulated lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human stimulated (GM-CSF + IL-4) peripheral blood mononuclear cells stained using anti-human CD207 (2G3) PE antibody (10 μl reagent per milion cells in 100 μl of cell suspension).
Figure 3: Separation of human CD207 positive CD11c positive dendritic cells differentiated upon monocyte stimulation (GM-CSF + IL-4) (red-filled) from non-stimulated lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human stimulated (GM-CSF + IL-4) peripheral blood mononuclear cells stained using anti-human CD207 (2G3) PE antibody (10 μl reagent per milion cells in 100 μl of cell suspension).