Anti-Hu CD32 FITC Mab (3D3)
Product Sizes
100 Tests
£581.00
30-2914-100TESTS
About this Product
- SKU:
- 30-2914
- Additional Names:
- FCG2; FCGR2A; IGFR2
- translate.label.attr.clone:
- 3D3
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Extra Details:
- Specificity: The mouse monoclonal antibody 3D3 recognizes an extracellular epitope of CD32; a 40 kDa polymorphic transmembrane glycoprotein serving as the low affinity receptor for aggregated IgG. This antibody recognizes CD32 isoforms on B cells of all donors; but on platelets; monocytes; and granulocytes of only some donors (131R variant; but not 131H variant). CD32 (FcgammaRII) is a low affinity receptor for aggregated IgG. It is strongly expressed on monocytes; granulocytes; myeloid and myeloblastic cell lines; and weakly on B cells; CD34+ bone marrow cells; and resting and activated platelets. After binding its ligand; CD32 induces IgG-mediated phagocytosis and oxidative burst in monocytes and neutrophils; whereas in B cells it mediates a negative signal. This polymorphic transmembrane glycoprotein is expressed not only in the activating (CD32a) and inhibitory isoform (CD32b); but also in individual variants with differing avidities for IgG subtypes (e.g. the CD32a131R and CD32a131H allotypes).
- Host:
- Mouse
- Immunogen:
- purified glycosylated recombinant human FcgammaRIIa2
- Isotype:
- Mouse IgG1 kappa
- Purification:
- Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
