Anti-Hu CD2 APC Mab (TS1/8)
Product Sizes
100 Tests
£620.00
30-2911-100TESTS
About this Product
- SKU:
- 30-2911
- Additional Names:
- T11; LFA-2; SRBC
- translate.label.attr.clone:
- TS1/8
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- Specificity: The mouse monoclonal antibody TS1/8 recognizes an extracellular epitope of CD2; a 50 kDa glycoprotein present on the human peripheral blood T lymphocytes and NK cells; also expressed by all thymocytes. CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover; T cell activation induces increased CD2 expression and its lateral mobility; making easier contact between CD2 and CD58. Subsequently; T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact; thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.
- Host:
- Mouse
- Immunogen:
- Cytotoxic T lymphocytes
- Isotype:
- Mouse IgG1 kappa
- Purification:
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
