Anti-Hu CD170 APC Mab (1A5)
Product Sizes
100 Tests
£620.00
30-2910-100TESTS
About this Product
- SKU:
- 30-2910
- Additional Names:
- OBBP2; OB-BP2; SIGLEC-5; SIGLEC5
- translate.label.attr.clone:
- 1A5
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- Specificity: The mouse monoclonal antibody 1A5 recognizes an extracellular epitope of CD170 (Siglec-5; sialic acid binding Ig-like lectin 5); a transmembrane glycoprotein expressed strongly by neutrophils; macrophages activated during infections; monocytes; and dendritic cells. As in case with other anti-CD170 antibodies; this antibody crossreacts with Siglec-14; whose first two Ig domains are almost identical to those of CD170. CD170; also known as Siglec 5 (sialic acid binding Ig-like lectin 5) is a type 1 transmembrane glycoprotein containing two cytoplasmic immunoreceptor tyrosine inhibitory motifs (ITIMs). CD170 forms homodimers and functions as an inhibitory receptor able to downregulate cell activation. It binds to alpha2;3- and alpha2;6-linked sialic acid ligands; e.g. on glycophorin A (CD235a). Aberrant expression of CD170 by CD34+ progenitor cells can be observed in case of acute myeloid leukemias.
- Host:
- Mouse
- Immunogen:
- Fusion protein composed of human CD170 extracellular domain and Fc region of human IgG1
- Isotype:
- Mouse IgG1
- Purification:
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
