Anti-Hu CD141 Mab (M80)
Product Sizes
0.1 mg
£541.00
30-2905-0.1MG
About this Product
- SKU:
- 30-2905
- Additional Names:
- Thrombomodulin; fetomodulin; THBD; THRM; THPH12; TM
- translate.label.attr.clone:
- M80
- Clonality:
- Monoclonal
- Extra Details:
- Specificity: The mouse monoclonal antibody M80 recognizes an extracellular epitope of CD141; a 75 kDa transmembrane glycoprotein expressed mainly on macrophages; monocytes; platelets and endothelial cells. CD141; also known as thrombomodulin or fetomodulin; is a single chain type I transmembrane glycoprotein serving as a receptor for thrombin and as an important cofactor in the protein C anticoagulant system; but it is also involved in embryonic and atherosclerotic plaque development. CD141 is expressed mainly on macrophages; monocytes; a subpopulation of myeloid dendritic cells; on platelets and endothelial cells; but also e.g. on keratinocytes (epithelium). After binding to thrombin; CD141 activates protein C; which degrades clotting factors Va and VIIIa; and as a consequence the amount of thrombin is reduced. Mutations in the CD141 gene can cause a thromboembolic disease known as inherited thrombophilia.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- MV4-11 cell line
- Isotype:
- Mouse IgG1
- Purification:
- Purified by protein-A affinity chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
