Anti-CD325 APC Mab(8C11)
Product Sizes
100 Tests
£620.00
30-2891-100TESTS
About this Product
- SKU:
- 30-2891
- translate.label.attr.clone:
- 8C11
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- Specificity: The mouse monoclonal antibody 8C11 recognizes an extracellular epitope of CD325 (N-cadherin); a transmembrane protein associated with actin cytoskeleton system; which is expressed mainly by neurons; osteoblasts; endothelial cells; and stem cells. CD325 (N-cadherin) is a type I transmembrane protein; which forms a complex with catenins; that is linked to the actin cytoskeleton. This complex is important in synapses and for functional plasticity of neurons; and is also essential for embryonic development. Decreased CD325 cleavage caused by mutations in presenilin 1 is associated with Alzheimer´s disease. Besides nervous system; CD325 is expressed on the surface of malignant T cells; and increases their adhesion to epithelia; as well as their ability to invade and metastasize to inflammatory sites.
- Host:
- Mouse
- Immunogen:
- bacterially expressed extracellular domain of human CD325
- Isotype:
- Mouse IgG1 kappa
- Purification:
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
