Anti-Hu CD172ab APC Mab(SE5A5)
Product Sizes
100 Tests
£620.00
30-2890-100TESTS
About this Product
- SKU:
- 30-2890
- Additional Names:
- PTPNS1; BIT; MFR; SIRPA; SHPS1; SIRPB1;
- translate.label.attr.clone:
- SE5A5
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- Specificity: The mouse monoclonal antibody SE5A5 recognizes a common extracellular epitope on human CD172a and CD172b antigens (approx. 90 kDa and approx. 50 kDa; respectively); although its reactivity with CD172a is higher. CD172a; the signal-regulatory protein alpha (SIRP alpha); also known as SH2 domain-containing phosphatase substrate-1 (SHPS1); is a 75-110 kDa transmembrane glycoprotein expressed mainly on granulocytes; monocytes; macrophages; dendritic cells and neurons. Its extracellular ligand is CD47. CD172a serves as a substrate of activated receptor tyrosine kinases and upon phosphorylation it recruits SH2 domain-containing tyrosine phosphatases; thereby regulating signal transduction processes related to cell activation; transmigration and phagocytosis. CD172a is a specific marker of cardiomyocytes derived from human pluripotent stem cells and serves as a negative regulator of signaling and growth in myeloid progenitor cells. Extracellular part of CD172b is 90% identical to that of CD172a; but unlike CD172; it has dramatically reduced intracellular domain.
- Host:
- Mouse
- Immunogen:
- NIH-3T3 / human CD172a cell line
- Isotype:
- Mouse IgG1
- Purification:
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
