Anti-Human CD368 APC Mab (Clone:9B9)
Product Sizes
100 tests
£620.00
30-2880-100TESTS
About this Product
- SKU:
- 30-2880
- Additional Names:
- CLEC6; CLEC4D; dectin 3; MCL; MPCL
- translate.label.attr.clone:
- 9B9
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- Specificity: The mouse monoclonal antibody 9B9 recognizes an extracellular epitope of CD368; a type II transmembrane protein of C lectin family; expressed mainly on monocytes and neutrophils. CD368 is an approximately 25-30 kDa C-type lectin; which serves as one of pattern recognition receptors of the innate immune system. It recognizes pathogen-associated molecular patterns of bacteria and fungi; such as alpha-mannans or trehalose 6;6´-dimycolate; and transfers the signal downstream using associated Fc receptor gamma chain. CD368 is expressed on neutrophils; monocytes; and on some populations of blood dendritic cells; but it decreases during differentiation of monocytes into dendritic cells or macrophages. Increased expression can be induced by IFN-gamma; TNF-alpha; IL-6; and IL-10. CD368 triggering leads to driving of antigen-presenting cells maturation and to promotion of T cell differentiation into Th1 and Th17.
- Host:
- Mouse
- Immunogen:
- CD368 ectodomain fused with human Fc
- Isotype:
- Mouse IgG2b kappa
- Purification:
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
