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Antibodies

APC Conjugated Anti-Human SIGLEC10 Mab (Clone: 5G6 )

Product Sizes
100 Tests
£620.00
30-2868-AC-100TESTS
About this Product
SKU:
30-2868-AC
Additional Names:
PRO940; SGL2; sialic acid binding Ig like lectin 10
translate.label.attr.clone:
5G6
Clonality:
Monoclonal
Conjugate:
APC
Extra Details:
Specificity : The mouse monoclonal antibody 5G6 recognizes an extracellular epitope of human SIGLEC10; a sialic acid-binding lectin expressed on subsets of human leucocytes. SIGLEC10 is a CD33-related receptor of sialoglycans; expressed on eosinophils; monocytes; a subpopulation of NK cells; and at lower level on B cells. Its murine ortholog is Siglec G. SIGLEC10 seems to act as an immunomodulatory receptor; which binds to VAP-1; a glycoprotein expressed on endothelium under inflammatory conditions. Another ligand of SIGLEC10 is CD24; a marker of poorer prognosis in carcinomas.
Format:
Purified
Host:
Mouse
Immunogen:
SIGLEC10 extracellular domain fused with human IgG1 Fc fragment
Isotype:
Mouse IgG1
Purification:
urified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at 2-8[o]C. Do not freeze. Avoid exposure to light.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
Figure 2: Separation of human SIGLEC10 positive non-classical monocytes (red-filled) from SIGLEC10 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human SIGLEC10 (5G6) APC antibody (10 μl reagent / 100 μl of peripheral whole blood).
Figure 2: Separation of human SIGLEC10 positive non-classical monocytes (red-filled) from SIGLEC10 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human SIGLEC10 (5G6) APC antibody (10 μl reagent / 100 μl of peripheral whole blood).